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This article MAO-A activity will be a 2 part series. But in the first recording, I believe I misspoke the name of the magazine so I just wanted to quickly clarify something. Correct name of the journal that published the study in the Journal reserpine Nervous and Mental Disease doctor was Dr. Lehman and others. Again, this study in 1957 used reserpine close between 3 and 7 mg in people with autism and found that this helped with socialization, communication, eyes and reduce self-stimulatory signals behavior. So if you want to look at this study again the doctor was Dr. Lehman and investigation in 1957 was published in The Journal of Nervous and Mental Disease.
So now I’d like to talk a little bit about how reserpine works. It is particularly enzymes to be aware of what is called monoamine oxidase A, or MAO-A for short. Now enzyme MAO-A is found inside cells and is important in helping the metabolism of three neurotransmitters, nor epinephrine, serotonin and histamine. And reserpine action MAO-A agonist. There seem to be many people out there who have been commenting that Respetar-A will inhibit MAO-A activity or that it will drain the MAO-A. But it is the role of MAO-A inhibitor and neither Respetar-A nor its active reserpine are MAO-A inhibitors. Some medicines more depression are MAO-A inhibitors, and reserpine is not a MAO-A inhibitor. What reserpine does is it increases metabolism, enzyme, MAO-A.
And what happens is that serotonin is converted into something called active aldehyde form her. The active aldehyde form, which is known as 5-hydroxyindole acetaldehyde, can then complicated by the synaptic receptors which then manifests as a physiological effect on the postsynaptic neuron. But over time, to do that you can cause serotonin depletion if you are using high doses of reserpine. You may also see this with Respetar-A use if you are not replenishing serotonin and keep protein levels adequate.
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