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There seems to be growing evidence that in autism, what we can see from the chemical, in the brain level, may have to do with serotonin imbalance. For many years it has been thought that people who have depression, mood problems, mood instability issues, learning difficulties, etc, could actually have a shortage of serotonin. It has been considered, even also with some of the kids on the autism that there may be a lack of serotonin which again can lead to some of the most irritating problems, behavioral problems, depressive episodes, as well as issues in learning, attention, etc. In many cases, if it’s real serious, children are placed on objects that help to stimulate serotonin or at least to keep serotonin production in the brain, so that things like Zoloft and Paxil and whatnot. And in some cases, it is help with some of the underlying issues of perception.
However, it may be what were looking at is well that we are not necessarily have a huge lack of serotonin, the active metabolite of serotonin is not produced sufficient. There is an enzyme in our body, it is active in the brain, called MAOA (monoamine oxidase inhibitors) it is actually two versions of MAO-A and MAO-B. MAO-A helps to convert serotonin, it also helps to convert norepinephrine and histamine but especially serotonin it actually helps to convert it into its active form. And when you convert it into an active form that serotonin works better and what we have seen progress in many of the underlying issues in the kids Spectrum less self-inducing behavior, improve the perception issues, attention, focus, learning ability.
And one interesting thing about serotonin if it is really too high it is inactive state, actually can inhibit oxytocin receptors, and we know that oxytocin is important for the eyes, facial expression recognition, socialization and even anxiety. So again, going back to understand the biochemical how things work in the brain is important and especially important in the state of autism.
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